84-4890-74　AGAP2 (Arf-GAP with GTPase, ANK Repeat and PH Domain-Containing Protein 2, ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2) 100ul　474877

特徴

• CENTG1 is a GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity.
• Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity.
• It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase.
• Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt.
• It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system.
• It seems to be oncogenic.
• It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.