Neurofibromin 2 (NF2) is a tumor suppressor gene encoding the protein Merlin.
Merlin is closely related to the ERM (ezrin, radixin, moesin) family of proteins.
The precise funtion of Merlin is not clear.
It is thought to provide a link between the actin cytoskeleten and membrane associated proteins, playing a role in transduction of extracellular signals.
It has been implicated in cell proliferation and cellular motility.
Mutations in the NF2 gene cause neurofibromatosis type II, a condition characterized by the development of tumors in the central nervous system.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:100Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes total human Merlin protein (aa516-520). Species Crossreactivity: mouse, rat.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Immunogen：Synthetic non-phosphopeptide derived from human Merlin around the phosphorylation site of serine 518 (R- L-SP-M-E).
