B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population.
Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE).
Also, some SLE patients have increased levels of BAFF in serum.
Therefore, it has been proposed that abnormally highlevels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.
The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain.
It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.
[provided by RefSeq]
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
AA Sequence:MRRGPRSLRGRDAPAPTPCVPAECFDLLVRHCVACG LLRTPRPKPAGASSPAPRTALQPQESVGAGAGEAALP LPGLLFGAPALLGLALVLALVLVGLVSWRRRQRRLRG ASSAEAPDGDKDAPEPLDKVIILSPGISDATAPAWPPP GEDPGTTPPGHSVPVPATELGSTELVTTKTAGPEQQ
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：mouse
Source Antibody：human
Grade：Purified
Purity：Purified
Form：Supplied as a liquid in PBS, pH 7.4.
Specificity：Recognizes human TNFRSF13C.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Protein corrsponding to aa1-184 from full length human TNFRSF13C.
