The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix.
In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells.
As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
[provided by RefSeq]
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
AA Sequence:MGAAARTLRLALGLLLLATLLRPADACSCSPVHPQQAF CNADVVIRAKAVSEKEVDSGNDIYGNPIKRIQYEIKQIK MFKGPEKDIEFIYTAPSSAVCGVSLDVGGKKEYLIAGK AEGDGKMHITLCDFIVPWDTLSTTQKKSLNHRYQMGC ECKITRCPMIPCYISSPDECLWMDWVTEKNINGHQAKF FACIKRSDGSCAWYRGAAPPKQEFLDIEDP
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：mouse
Source Antibody：human
Grade：Purified
Purity：Purified
Form：Supplied as a liquid in PBS, pH 7.4.
Specificity：Recognizes human TIMP2
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Protein corresponding to aa1-220 from full length human TIMP2
