84-4882-64　PCSK9 (FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1) 50ug　470102

特徴

• This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family.
• The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum.
• The protein may function as a proprotein convertase.
• This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons.
• Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
• [provided by RefSeq]
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• AA Sequence:MGTVSSRRSWWPLPLLLLLLLLLGPAGARAQEDEDGD YEELVLALRSEEDGLAEAPEHGTTATFHRCAKDPWRL PGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKIL HVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVF AQSIPWNLERITPPRYRADEYQPPDGGSLVEVYLLDTS IQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDS HGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTV SGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAA CQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVG ATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDC STCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELR QRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHG AGWQLFCRTVWSAHSGPTRMATAVARCAPDEELLSC SSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVY AIARCCLLPQANCSVHTAPPAEASMGTRVHCHQQGH VLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGHRE ASIHASCCHAPGLECKVKEHGIPAPQEQVTVACEEGW TLTGCSALPGTSHVLGAYAVDNTCVVRSRDVSTTGST SEGAVTAVAICCRSRHLAQASQELQ
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.