Proprotein convertases, including PCSK4, are calcium-dependent serine proteases related to bacterial subtilisins and to yeast kexin.
These enzymes process precursor proteins to their active forms by selective cleavage of the polypeptide at sites following paired basic amino acids.
In mammals, this family comprises PC1 (MIM 162150), PC2 (MIM 162151), PC4, PC5 (MIM 600488), furin (FUR; MIM 136950), and PACE4 (MIM 167405).
Substrates for these enzymes range from prohormones to precursors for growth factors to cell surface receptors and viral surface glycoproteins (Cao et al., 2001 [PubMed 11776387]).[supplied by OMIM]
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
AA Sequence:MGTRSTLVAIRPLDVSTEGYNNWVFMSTHFWDENPQ GVWTLGLENKGYYFNTGTLYRYTLLLYGTAEDMTARP TGPQVTSSACVQRDTEGLCQACDGPAYILGQLCLAYC PPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCR GGSPRDCTSCPPSSTLDQQQGSCMGPTTPDSRPRLR AAACPHHRCPASAMVLSLLAVTLGGPVLCGMSMDLPL YAWLSRARATPTKPQVWLPAGT
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：mouse
Source Antibody：human
Grade：Purified
Purity：Purified
Form：Supplied as a liquid in PBS, pH 7.4.
Specificity：Recognizes PCSK4. Species Crossreactivity: Human, Rat.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Rt
Immunogen：Protein corresponding to aa1-242 from full length human PCSK4.
