84-4882-45　NFKB1 (DKFZp686C01211, EBP-1, KBF1, MGC54151, NF-kappa-B, NFKB-p105, NFKB-p50, p105, p50) 50ul　470083

特徴

• This gene encodes a 105kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50kD protein.
• The 105kD protein is a Rel protein-specific transcription inhibitor and the 50kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex.
• NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products.
• Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions.
• Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth.
• Two transcript variants encoding different isoforms have been found for this gene.
• [provided by RefSeq]
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• AA Sequence:MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMAL PTADGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGAS SEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAH SLVGKHCEDGICTVTAGPKDMVVGFANLGILHVTKKKV FETLEARMTEACIRGYNPGLLVHPDLAYLQAEGGGDR QLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDS TGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGC VTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFG DFSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKS DLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNFSDSF GGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPH YGFPTYGGITFHPGTTKSNAGMKHGTMDTESKKDPE GCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGEV TLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFD YAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHS QLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQE DVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSI LLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLV AAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEG DAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPL VENFEPLYDLDDSWENAGEDEGVVPGTTPLDMATSW QVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQL YKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTL MDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPV KTTSQAHSLPLSPASTRQQIDELRDSDSVCDSGVETS FRKLSFTESLTSGASLLTLNKMPHDYGQEGPLEGKI
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.