84-4881-46　F7 50ug　469980

特徴

• This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis.
• This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis.
• Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond.
• In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa.
• Alternative splicing of this gene results in 2 transcripts.
• Defects in this gene can cause coagulopathy.
• [provided by RefSeq]
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• AA Sequence:MVSQALRLLCLLLGLQGCLAAVFVTQEEAHGVLHRRR RANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERT KLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLP AFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKR SCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASK PQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINT IWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQS RRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPL CLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELM VLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSD GSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCA TVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.