84-4881-37　DOK1 (MGC117395, MGC138860, P62DOK) 50ul　469968

特徴

• Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase.
• It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML.
• Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs.
• Docking protein 2 binds p120 (RasGAP) from CML cells.
• It has been postulated to play a role in mitogenic signaling.
• [provided by RefSeq]
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• AA Sequence:MDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPH GVARLEFFDHKGSSSGGGRGSSRRLDCKVIRLAECVS VAPVTVETPPEPGATAFRLDTAQRSHLLAADAPSSAA WVQTLCRNAFPKGSWTLAPTDNPPKLSALEMLENSLY SPTWEGSQFWVTVQRTEAAERCGLHGSYVLRVEAER LTLLTVGAQSQILEPLLSWPYTLLRRYGRDKVMFSFEA GRRCPSGPGTFTFQTAQGNDIFQAVETAIHRQKAQGK AGQGHDVLRADSHEGEVAEGKLPSPPGPQELLDSPP ALYAEPLDSLRIAPCPSQDSLYSDPLDSTSAQAGEGV QRKKPLYWDLYEHAQQQLLKAKLTDPKEDPIYDEPEG LAPVPPQGLYDLPREPKDAWWCQARVKEEGYELPYN PATDDYAVPPPRSTKPLLAPKPQGPAFPEPGTATGSGI KSHNSALYSQVQKSGASGSWDCGLSRVGTDKTGVKS EGST
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.