This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein.
The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6.
During hematopoietic cell differentiation, this gene is down-regulated.
It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression.
Multiple transcript variants encoding several different isoforms have been found for this gene.
[provided by RefSeq]
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
AA Sequence:MSRRKQGKPQHLSKREFSPEPLEAILTDDEPDHGPLG APEGDHDLLTCGQCQMNFPLGDILIFIEHKRKQCNGSL CLEKAVDKPPSPSPIEMKKASNPVEVGIQVTPEDDDCL STSSRGICPKQEHIADKLLHWRGLSSPRSAHGALIPTP GMSAEYAPQGICKDEPSSYTCTTCKQPFTSAWFLLQH AQNTHGLRIYLESEHGSPLTPRVLHTPPFGVVPRELKM CGSFRMEAREPLSSEKI
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：mouse
Source Antibody：human
Grade：Purified
Purity：Purified
Form：Supplied as a liquid in PBS, pH 7.4.
Specificity：Recognizes human BCL11A
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Protein corresponding to aa1-243 from full length human BCL11A
