84-4872-62　PSTPIP1 (Proline-serine-threonine Phosphatase-interacting Protein 1, PEST Phosphatase-interacting Protein 1, CD2-binding Protein 1, H-PIP, PSTPIP1, CD2BP1) 50ul　406958

特徴

• Involved in regulation of the actin cytoskeleton.
• May regulate WAS actin-bundling activity.
• Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation.
• May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS.
• Has the potential to physically couple CD2 and CD2AP to WAS.
• Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity).
• Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2.
• Also has a role in innate immunity and the inflammatory response.
• Recruited to inflammasomes by MEFV.
• Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis.
• Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation.
• Regulates endocytosis and cell migration in neutrophils.
• Applications:Suitable for use in ELISA, Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:1000-1:5000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.