Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission.
Function is isoform-specific.
Alpha-type isoforms have a long N-terminal with six laminin G-like domains and play an important role in synaptic signal transmission.
Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions.
They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland.
They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery.
Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels.
Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2.
In vitro, triggers the de novo formation of presynaptic structures.
May be involved in specification of excitatory synapses.
Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom (By similarity).
Applications:Suitable for use in ELISA, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:20-1:200 Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human NRXN1.
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa31-310 of human NRXN1.
