84-4861-69　EPHB1 (Ephrin Type-B Receptor 1, ELK, EPH Tyrosine Kinase 2, EPH-like Kinase 6, EK6, hEK6, Neuronally-expressed EPH-related Tyrosine Kinase, NET, Tyrosine-protein Kinase Receptor EPH-2, EPHB1, ELK, EPHT2, HEK6, NET) 50ul　406417

特徴

• Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.
• The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.
• Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3.
• During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline.
• This probably requires repulsive interaction with EFNB2.
• In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors.
• In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation.
• May also regulate angiogenesis.
• More generally, may play a role in targeted cell migration and adhesion.
• Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively.
• Applications:Suitable for use in ELISA, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: 1:20-1:200 Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.