Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:7760007, PubMed:15496415, PubMed:15048703, PubMed:16352806, PubMed:23169771, PubMed:24945728).
Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:15048703, PubMed:16352806, PubMed:24945728).
Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:15294938, PubMed:16352806).
Mediates homotypic interactions with cells that express ALCAM (PubMed:15496415, PubMed:16352806).
Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813).
Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:23169771).
Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:15496415, PubMed:23169771).
Required for normal organization of the lymph vessel network.
Required for normal hematopoietic stem cell engraftment in the bone marrow.
Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow.
Promotes in vitro osteoblast proliferation and differentiation (By similarity).
Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM.
Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity).
Applications:Suitable for use in ELISA, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:20-1:200 Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human ALCAM.
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa28-180 of human ALCAM.
