84-4690-83　SDHB (Succinate Dehydrogenase [Ubiquinone] Iron-Sulfur Subunit, Mitochondrial, Iron-Sulfur Subunit of Complex II, Ip, SDH, SDH1) 100ug　397546

特徴

• SDHB (Succinate Dehydrogenase Complex, Subunit B, iron sulfur protein), also known as iron-sulfur subunit of complex II (Ip) or SDH2, HOMOLOG OF, is a protein that in humans is encoded by the SDHB gene.
• SDHB is one of four protein subunits forming succinate dehydrogenase, the other three being SDHA, SDHC and SDHD.
• The SDHB subunit is connected to the SDHA subunit on the hydrophilic, catalytic end of the SDH complex.
• The SDHB gene is mapped on 1p36.13.
• It is stated that the nuclear-encoded Krebs cycle enzymes fumarate hydratase and succinate dehydrogenases like SDHB act as tumor suppressors, and germline mutations in these genes predispose individuals to leiomyomas and renal cancer and to paragangliomas, respectively.
• In affected members of families with paragangliomas-4, mutations were identified in the SDHB gene.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 0.1-0.5ug/mlWestern Blot: 0.1-0.5ug/mlImmunohistochemistry (paraffin): 0.5-1ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.