84-4690-52　Plaur (Urokinase Plasminogen Activator Surface Receptor, U-PAR, uPAR, CD87) 100ug　397515

特徴

• PLAUR (PLASMINOGEN ACTIVATOR RECEPTOR, UROKINASE-TYPE), also known as UPAR or CD87, is multidomain glycoprotein tethered to the cell membrane with a glycosylphosphotidylinositol (GPI) anchor.
• PLAUR consists of three different domains of the Ly-6/uPAR/alpha-neurotoxin family.
• PLAUR is originally identified as a saturable binding site for urokinase on the cell surface.
• And the gene plays an important role in many normal as well as pathologic processes.
• The PLAUR gene is localized to 19q13.31.
• PLAUR is a part of the plasminogen activation system, which in the healthy body is involved in tissue reorganization events such as mammary gland involution and wound healing.
• PLAUR binds urokinase and thus restricts plasminogen activation to the immediate vicinity of the cell membrane.
• Thus it seems to be an important player in the regulation of this process.
• In human coronary artery vascular smooth muscle cells, UPA stimulates cell migration via a UPAR signaling complex containing TYK2 and phosphatidylinositol 3-kinase.
• Applications:Suitable for use in ELISA, Western Blot.
• Other applications not tested.
• Recommended Dilution:ELISA: 0.1-0.5ug/mlWestern Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.