84-4690-38　NRXN1 (Neurexin-1-Beta, Neurexin I-Beta) 100ug　397501

特徴

• Neurexin-1-alpha is a protein that in humans is encoded by the NRXN1 gene.
• This gene encodes a single-pass type I membrane protein that belongs to the neurexin family.
• Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system.
• This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts.
• Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member.
• Recently, a third promoter (gamma) was identified for this gene in the 3' region.
• Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia.
• Applications:Suitable for use in ELISA, Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.