84-4690-19　MUC2 (Mucin-2, MUC-2, Intestinal Mucin-2, SMUC) 100ug　397480

特徴

• Mucin 2, also known as MUC2, is a protein that in humans is encoded by the MUC2 gene.
• This gene encodes a member of the mucin protein family.
• It is mapped to 11p15.5.
• Mucin 2 is particularly prominent in the gut where it is secreted from goblet cells in the epithelial lining into the lumen of the large intestine.
• There, mucin 2, along with small amounts of related-mucin proteins, polymerizes into a gel of which 80% by weight is oligosaccharide side-chains that are added as post-translational modifications to the mucin proteins.
• This gel provides an insoluble mucous barrier that serves to protect the intestinal epithelium.
• The primary function of the MUC2 gene product is to provide a protective barrier between the epithelial surfaces and the gut lumen.
• There is decreased expression of MUC2 in colonic cancer and defective polymerization of secreted mucin in ulcerative colitis.
• Applications:Suitable for use in Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry (paraffin): 0.5-1ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.