84-4690-02　JAK1 (Tyrosine-Protein Kinase JAK1, 2.7.10.2, Janus Kinase 1, JAK-1, JAK1A, JAK1B) 100ug　397462

特徴

• JAK1 (JANUS KINASE 1) is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines.
• It is a member of a new class of PTKs that are a large family of proteins characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain--hence the name Janus.
• The JAK1 gene is mapped to 1p31.3.
• JAK1 is also important for transducing a signal by type I (IFN-alpha/beta) and type II (IFN-γ) interferons, and members of the IL-10 family via type II cytokine receptors.
• Additionally, Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families.
• Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling.
• Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.