84-4689-98　ITGAL (Integrin Alpha-L, CD11 Antigen-Like Family Member A, Leukocyte Adhesion Glycoprotein LFA-1 Alpha Chain, LFA-1A, Leukocyte Function-Associated Molecule 1 Alpha Chain, CD11a, ITGAL, CD11A) 100ug　397459

特徴

• CD11a, also known as ITGAL or LFA-1, is a human gene which functions in the immune system.
• It is mapped to 16p11.2.
• CD11a is involved in cellular adhesion and costimulatory signaling.
• It is the target of the drug efalizumab.
• CD11a encodes the integrin alpha L chain.
• Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain.
• This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes.
• CD11a plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling.
• It is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1.
• Applications:Suitable for use in Flow Cytometry, Western Blot, Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:Flow Cytometry: 1-3ug/1x10e6 cellsWestern Blot: 0.1-0.5ug/mlImmunohistochemistry (frozen): 0.5-1ug/mlImmunocytochemistry: 0.5-1ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.