84-4689-23　COL18A1 (Collagen Alpha-1(XVIII) Chain, Endostatin) 100ug　397379

特徴

• Collagen alpha-1(XVIII) chain is a protein that in humans is encoded by the COL18A1 gene.
• This gene encodes the alpha chain of type XVIII collagen.
• This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains.
• A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors.
• Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth.
• Mutations in this gene are associated with Knobloch syndrome.
• The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure.
• Alternative splicing results in multiple transcript variants.
• Applications:Suitable for use in ELISA, Western Blot.
• Other applications not tested.
• Recommended Dilution:ELISA: 1-5ug/mlWestern Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.