84-4688-96　CCR3 (C-C Chemokine Receptor Type 3, C-C CKR-3, CC-CKR-3, CCR-3, CKR3, Eosinophil Eotaxin Receptor, CD193, CMKBR3) 100ug　397353

特徴

• C-C chemokine receptor type 3, also called CCR3 or CKR3 is a protein that in humans is encoded by the CCR3 gene.
• The protein encoded by this gene is a receptor for C-C type chemokines.
• It belongs to family 1 of the G protein-coupled receptors.
• This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21.
• This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5).
• It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells.
• This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway.
• It is also known to be an entry co-receptor for HIV-1.
• Alternatively spliced transcript variants have been described.
• Applications:Suitable for use in Flow Cytometry, Western Blot, Immunohistochemistry and Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:Flow Cytometry: 1-3ug/1x10e6 cellsWestern Blot: 0.1-0.5ug/mlImmunohistochemistry (frozen): 0.5-1ug/mlImmunocytochemistry: 0.5-1ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.