STAT5A plays an important role in cell growth, survival, differentiation and transformation by transducing signals from cytokine receptors to the nucleus.
STAT5A is tyrosine phosphorylated by members of the Janus kinase (JAK) family in response to cytokines and growth factor stimulation.
Phosphorylation results in STAT activation and the formation of STAT5 homo- and STAT5/STAT3 heterodimers.
STAT dimers translocate from the cytoplasm to the nucleus where they act as transcription factors.
Deregulated JAK/STAT signaling has been implicated in a variety of cancers, and STATs can regulate the tumor microenvironment to trigger a shift from cancer inhibition to promotion.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, 0.2% gelatin, 0.09% sodium azide.
Specificity：Recognizes mouse STAT5A. Species Crossreactivity: human, rat.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to mouse STAT5A, at C-terminal.
