p38 alpha (p38-alpha MAPK), also known as MAP kinase 14 (MAPK14) and stress activated protein kinase 2a (SAPK2a).
p38 alpha is a member of the p38 MAPK serine/threonine kinase protein family, which also includes p38-beta (MAPK11), p38-gamma (MAPK12) and p38-delta (MAPK13).
p38 alpha MAPK becomes activated in response to a variety of stimuli, which include inflammatory cytokines and oxidative stress.
p38 alpha MAPK plays an essential role in mediating inflammation by regulating the expression of tumor necrosis factor alpha (TNF alpha) and interleukin 1 (IL-1).
p38 MAPK proteins have been implicated in cancer development and p38 alpha MAPK has been proposed to act as a tumor suppressor.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, 0.2% gelatin, 0.09% sodium azide.
Specificity：Recognizes mouse p38 Alpha MAPK. Species Crossreactivity: rat, human.
Isotype：IgG
Calc Applications Abbrev：E
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to mouse p38 alpha MAPK at C-terminal. Species sequence homology: human (100%)
