Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles.
Calcium binds to Synaptotagmin I which triggers neurotransmitter release at the synapse.
Synaptotagmin II is phosphorylated by WNK1 in a process that regulates calcium-dependent interactions.
Synaptotagmin III is involved in calcium-dependent exocytosis of secretory vesicles in endocrine cells and neurons.
Synaptotagmin IV is expressed in neuronal tissues, and has the highest mRNA levels in the hippocampus.
The proximity of the Synaptotagmin IV gene to markers of several psychiatric disorders suggest an involvement of synaptotagmin IV in human disease.
Synaptotagmin V is a dense-core vesicle-specific protein that regulates a specific type of calcium-regulated secretion.
Synaptotagmin VI interacts with adaptor protein-2 in a calcium-independent manner.
Synaptotagmin VII is widely expressed in non-neuronal tissues.
Applications:Suitable for use in ELISA, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：20ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide, 50% glycerol.
Specificity：Recognizes human SYT4. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant protein corresponding to human SYT4.
