This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family.
The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins.
The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis.
Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:2000-5000Immunohistochemistry: 1:25-100Western Blot: 1:500-2000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：20ul
Host：rabbit
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide, 50% glycerol.
Specificity：Recognizes SIAH1. Species Crossreactivity: human, mouse and rat
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Full length fusion protein corresponding to SIAH1.
