84-4629-46　［取扱停止］PSME3 20ul　393457

特徴

• The 20S proteasome is the major proteolytic enzyme complex involved in intracellular protein degradation.
• PA700, PA28, and PA200 are three major protein complexes that function as activators of the 20S proteasome.
• There are three evolutionarily conserved subunits of PA28: PA28alpha (PSME1), PA28beta (PSME2), and PA28γ (PSME3).
• PA28alpha and PA28beta form a heteroheptameric complex and function by binding to the 20S complex at its opening site(s).
• The PA28alpha/beta complex is present throughout the cell and participates in MHC class I antigen presentation by promoting the generation of antigenic peptides from foreign proteins.
• PA28γ exists in the form of a homoheptamer and is mainly located in the nucleus.
• The PA28γ complex exerts its function by binding and guiding specific nuclear target proteins to the 20S proteasome for further degradation.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.