84-4606-62　［取扱停止］NPPC 200ul　392326

特徴

• This gene encodes a member of the Notch family.
• Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types.
• Notch family members play a role in a variety of developmental processes by controlling cell fate decisions.
• The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells.
• In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development.
• Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined.
• This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer.
• This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development.
• This gene may be associated with susceptibility to schizophrenia in a small portion of cases.
• An alternative splice variant has been described but its biological nature has not been determined.
• Applications:Suitable for use in ELISA, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.