84-4597-72　［取扱停止］MYH11 20ul　391886

特徴

• The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family.
• The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits.
• It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP.
• The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter.
• The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain.
• This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype.
• Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation.
• Alternatively spliced transcript variants encoding different isoforms have been identified.
• Applications:Suitable for use in ELISA, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: 1:25-1:100Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.