Leucine-rich repeats (LRRs) are 20-29 amino acid motifs that mediate protein-protein interactions.
The primary function of these motifs is to provide a versatile structural framework for the formation of these protein-protein interactions.
LRRs are present in a variety of proteins with diverse structure and function, including innate immunity and nervous system development.
Several human diseases are associated with mutations in genes encoding LRR-containing proteins.
The leucine-rich repeat-containing protein 15 (LRRC15, also designated LIB) is a 581 amino acid protein that contains 15 LRR repeats and is involved in cell-cell and/or -extracellular matrix interactions.
LRRC15 is frequently overexpressed in multiple tumor types, most notably breast carcinoma.
It is also associated with the pathogenesis of Alzheimer’s disease.
Applications:Suitable for use in ELISA, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：20ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide, 50% glycerol.
Specificity：Recognizes human LRRC15. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant protein corresponding to human LRRC15.
