Ankyrin repeat-rich membrane-spanning protein (ARMS), also designated kinase D-interacting substance 220 or Kidins220, is a highly conserved protein containing multiple domains, including four putative transmembrane domains and several ankyrin repeats.
ARMS is expressed in regions rich in neurotrophin (Trk) and ephrin (Eph) receptors, such as the brain and neuroendocrine cells (where it concentrates at the tip of neurites) and in plastic areas of the adult brain.
It is also detected in peripheral blood immature dendritic cells and PC12 cells.
ARMS functions as a substrate for protein kinase D and is a downstream target for both Trk and Eph receptors.
It is a highly conserved protein, which suggests it has an evolutionary conserved role.
The gene encoding for the protein maps to chromosome 2p24.
Applications:Suitable for use in ELISA, Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:200-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：20ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide, 50% glycerol.
Specificity：Recognizes human KIDINS220. Species Crossreactivity: rat
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Rt
Immunogen：Synthetic peptide corresponding to human KIDINS220.
