Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies.
It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages.
It also enhances B cell survival, proliferation, and antibody production.
IL-10 can block NF-kB activity, and is involved in the regulation of the JAK-STAT signaling pathway.
IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases.
IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:50-1:100Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes mouse IL10. Species Crossreactivity: rat
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Mo Rt
Immunogen：Recombinant protein corresponding to mouse Interleukin-10.
