The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family.
It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells.
Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens.
Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10.
Prevents the apoptosis of pre-activated T-cells.
Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
Applications:Suitable for use in ELISA, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:20-1:100 Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：20ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide, 50% glycerol.
Specificity：Recognizes human ICOS.
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to human ICOS.
