This gene encodes a weak acid-active hyaluronidase.
The encoded protein is similar in structure to other more active hyaluronidases.
Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix.
Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation.
Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein.
This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus.
The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression.
This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.
Applications:Suitable for use in ELISA, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:100-1:300 Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：20ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide, 50% glycerol.
Specificity：Recognizes human HYAL2. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant protein corresponding to human HYAL2.
