HtrA3, also known as PRSP (pregnancy-related serine protease), is a 453 amino acid secreted protein that contains one PDZ domain, one Kazal-like domain and one IGFBP N-terminal domain.
Widely expressed with particularly high expression in ovary, heart, placenta and bladder, HtrA3 functions as a probable serine protease that is thought to play an important role in placental development.
HtrA3 is downregulated in ovarian tumors, suggesting an alternative role in tumor suppression.
HtrA3 exists as two alternatively spliced isoforms, designated short and long.
The gene encoding HtrA3 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes.
Applications:Suitable for use in ELISA, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：20ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide, 50% glycerol.
Specificity：Recognizes human HTRA3. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human HTRA3.
