84-4544-83　［取扱停止］FOXO3 20ul　389268

特徴

• This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain.
• This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death.
• Translocation of this gene with the MLL gene is associated with secondary acute leukemia.
• Alternatively spliced transcript variants encoding the same protein have been observed.
• Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration.
• Upon oxidative stress, interacts with STK4/MST1, which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation.
• Interacts with PIM1.
• Interacts with DDIT3/CHOP.
• Applications:Suitable for use in ELISA, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: 1:50-1:150Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.