84-4542-21　［取扱停止］FGFR3 20ul　389138

特徴

• This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species.
• FGFR family members differ from one another in their ligand affinities and tissue distribution.
• A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain.
• The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.
• This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance.
• Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.
• Three alternatively spliced transcript variants that encode different protein isoforms have been described.
• Applications:Suitable for use in ELISA, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: 1:35-1:150Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.