Beclin-1 is a protein that in humans is encoded by the BECN1 gene.
Beclin-1 is also known as autophagy-related gene (Atg) 6.
Beclin-1 and its binding partner class III phosphoinositide 3-kinase (PI3K), also named Vps34, which are participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration.
Plays a central role in autophagy.
Required for the abcission step in cytokinesis.
May play a role in antiviral host defense.
Protects against infection by a neurovirulent strain of Sindbis virus.
Interacts with GOPC and GRID2.
Interacts with AMBRA1.
Forms a complex with PIK3C3 and PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14.
UVRAG and ATG14 form mutually exclusive complexes through direct competition for BECN1-binding.
Applications:Suitable for use in ELISA, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:10-1:50Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide, 50% glycerol.
Specificity：Recognizes human BECN1. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human BECN1.
