84-4486-28　［取扱停止］BCAS2 200ul　386368

特徴

• BCAS2 (breast carcinoma amplified sequence 2), also designated DAM1 (DNA amplified in mammary carcinoma 1 protein) or spliceosome-associated SPF 27, is a ubiquitously expressed nuclear protein that was originally identified as being overexpressed in various breast cancer cell lines.
• BCAS2 is now known to be a component of the spliceosome, participating in the removal of introns from mRNA precursors.
• BCAS2 specifically interacts (in a ligand-independent manner) with TR∫ (thyroid hormone receptor beta), ERå (estrogen receptor alpha), ER∫, PR (progesterone receptor), and PPAR© (Peroxisome proliferator-activated receptor gamma).
• BCAS2 functions as an ER coactivator and is capable of enhancing ER-mediated transcription.
• This suggests that BCAS2 is involved in the development of breast cancer.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:200-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.