Abeta derives from APP via proteolytic cleavage by proteases called alpha-, beta- and gamma-secretase.
The alpha-secretase cleavage precludes the formation of Abeta, while the beta- and gamma-cleavages generate APP components with amyloidogenic features.
Amyloid beta A4 precursor protein(APP), encoded by APP gene which locate on human chromosome 21q, is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
APP expressed in all fetal tissues and is pronounced in brain, kidney, heart and spleen, but weak in liver.
Defects in APP are the cause of Alzheimer disease type 1 (AD1).
This antibody can recognize the N-terminus of human APP: Soluble APP-alpha and Soluble APP-beta.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:50-1:100Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：20ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human AB40. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant protein corresponding to human Beta-amyloid 40.
