84-4460-11　Alpha Synuclein, phosphorylated (pSer129) (Alpha-Synuclein, Alpha-Synuclein, Isoform NACP140, AlphaSYN, NACP, Non A Beta Component Of AD Amyloid, Non A4 Component Of Amyloid, Non A4 Component Of Amyloid Precursor, Non-A Beta Component Of AD Amyloid, Non-A-Beta Component Of Alzheimers Disease Amyloid, Non-A4 Component Of Amyloid Precursor, Non-A4 Component Of Amyloid, PARK 1, PARK 4, PARK1, PAR ...　385058

特徴

• Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1).
• Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2).
• Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein.
• It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4).
• SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson’s disease.
• Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).
• Alpha synuclein phosphorylated at serine 129 constitutes 90% of the alpha synuclein found in Lewy bodies (7, 8).
• Applications:Suitable for use in Western Blot, ELISA, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:1000Immunohistochemistry: 1:500Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.