84-4460-08　ROR2 (NTRKR2, Tyrosine-Protein Kinase Transmembrane Receptor ROR2, Receptor-Related 2, ROR2, Neurotrophic Tyrosine Kinase, Receptor Tyrosine Kinase-Like Orphan Receptor 2, Neurotrophic Tyrosine Kinase, Receptor Related 2) 100ug　385055

特徴

• ROR2 is a receptor tyrosine kinase which may have a role in early cartilage and growth plate development.
• ROR2 expression is generally highest during embryonic development and will gradually decrease as cells terminally differentiate.
• Wnt5a has been identified to utilize ROR2 as a co-receptor for non-canonical Wnt signalling.
• Aberrant expression of ROR2 has been implicated in gastric, osteosarcoma, mestatic melanoma, prostate, renal cell and squamous cell carcinomas.
• Increased expression of ROR2 was correlated with increased metastasis.
• In prostate, osteosarcomas and metastatic melanomas, Wnt5a/ROR2 receptor complex formation was implicated as the mechanism for cancer progression.
• ROR2 seems to function as an oncogene.
• Primarily mis-sense mutations of ROR2 have been identified in tumors but their functional effect has not been well characterized.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.