TSHR (Thyroid-Stimulating Hormone Receptor), also called LGR3, is mapped to 14q31.1.
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism.
The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase.
Defects in this gene are a cause of several types of hyperthyroidism.
Three transcript variants encoding different isoforms have been found for this gene.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Stable for 12 months after receipt at -20°C.
Reconstitute with sterile dH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder in 5mg/ml BSA, 0.9mg sodium chloride, 0.2mg Na2HPO4, 0.05% sodium azide. Reconstitute with 200ul sterile ddH2O to ~0.5mg/ml.
Specificity：Recognizes human TSHR. Species Crossreactivity: rat and mouse
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa244-277, KGLEHLKELIARNTWTLKKLPLSLSFLHLTRADL from human TSHR at N-terminal, different from the related mouse sequence by 2aa, and from the related rat sequence 1aa.
