84-4458-57　THBS1 (Thrombospondin-1) 100ug　377620

特徴

• THBS1 is also known as Thrombospondin 1, TSP1.
• The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein.
• It is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions.
• This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1.
• It has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.
• In addition, the thrombospondin-1 protein is a member of the thrombospondinfamily.
• It is a multi-domain matrix glycoprotein that has been shown to be a natural inhibitor of neovascularization and tumorigenesis in healthy tissue.
• Both positive and negative modulation of endothelial cell adhesion, motility, and growth have been attributed to TSP1.
• This should not be surprising considering that TSP1 interacts with at least 12 cell adhesion receptors, including CD36, alpha v integrins, beta 1 integrins, syndecan, and integrin-associated protein (IAP or CD47).
• It also interacts with numerous proteases involved in angiogenesis, including plasminogen, urokinase, matrix metalloproteinase,thrombin, cathepsin, and elastase.
• Applications:Suitable for use in ELISA, Western Blot.
• Other applications not tested.
• Recommended Dilution:ELISA: 0.1-0.5ug/mlWestern Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile dH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.