84-4457-59　MyD88 100ug　377517

特徴

• MYD88, Myeloid Differentiation Primary Response Gene 88, is a protein that, in humans, is encoded by the MYD88 gene.
• MyD88 is a key downstream adapter for most Toll-like receptors (TLRs) and interleukin-1 receptors (IL1Rs).
• And it is mapped on 3p22.2.
• MYD88 encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response.
• This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways.
• Overexpression of MYD88 caused an increase in the level of transcription from the interleukin-8 promoter.
• The C-terminal domain of MYD88 has significant sequence similarity to the cytoplasmic domain of IL1RAP.
• Inhibiting the IL1R-MYD88 pathway in vivo could block the damage from acute inflammation that occurs in response to sterile cell death, and do so in a way that might not compromise tissue repair or host defense against pathogens.
• Applications:Suitable for use in ELISA, Western Blot.
• Other applications not tested.
• Recommended Dilution:ELISA: 0.1-0.5ug/mlWestern Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile dH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.