84-4457-56　MUC1 100ug　377514

特徴

• Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in humans.
• This gene encodes a membrane-bound protein that is a member of the mucin family.
• Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces.
• It is mapped to 1q22.
• Mucin 1 is a transmembrane mucin normally expressed on the apical borders of secretory epithelial cells.
• Overexpression of Mucin 1 is often associated with colon, breast, ovarian, lung and pancreatic cancers.
• The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity.
• Mucin 1 stimulated ESR1-mediated transcription and contributed to estradiol-mediated growth and survival of breast cancer cells.
• This gene also can suppress pulmonary innate immunity, and its antiinflammatory activity may play an important modulatory role during microbial infection.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 0.1-0.5ug/mlWestern Blot: 0.1-0.5ug/mlImmunohistochemistry (paraffin): 0.5-1ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile dH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.