84-4457-37　MC1 Receptor (Melanocyte-stimulating Hormone Receptor) 100ug　377495

特徴

• The melanocortin 1 receptor (MC1R), mapped to 16q24.3, is also known as MSHR.
• This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH).
• The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis.
• Two types of melanin exist: red pheomelanin and black eumelanin.
• Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color.
• Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation.
• Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis.
• This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer.
• Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile dH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.