Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene.
It is mapped to 17q21.32.
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain.
Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation.
Mutations that interfere with this role result in thrombasthenia.
In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
Applications:Suitable for use in ELISA, Flow Cytometry, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Flow Cytometry: 1-3ug/1x10e6 cells ELISA: 0.1-0.5ug/mlImmunohistochemistry (paraffin): 0.5-1ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Stable for 12 months after receipt at -20°C.
Reconstitute with sterile dH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder in 5mg/ml BSA, 0.9mg sodium chloride, 0.2mg Na2HPO4, 0.05% sodium azide. Reconstitute with 200ul sterile ddH2O to ~0.5mg/ml.
Specificity：Recognizes human ITGA2B. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E FC IHC
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant protein corresponding to human ITGA2B (Position: L32-D263) expressed in E. coli.
