The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the IL1RN gene.
The protein encoded by this gene is a member of the interleukin 1 cytokine family.
This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses.
This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400kb on chromosome 2.
A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer.
Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 0.1-0.5ug/mlWestern Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C.
Reconstitute with sterile dH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% sodium azide, 0.05% thimerosal. Reconstitute with 200ul sterile ddH2O
Specificity：Recognizes human IL1RA.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to human IL1RA, expressed in E. coli. (Position: R26-E177). Species sequence homology: mouse (77%), rat (75.5%).
