84-4455-83　DYNLT1 100ug　377333

特徴

• Dynein light chain Tctex-type 1 is a protein that in humans is encoded by the DYNLT1 gene.
• This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell.
• The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells.
• The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus.
• This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation.
• Pseudogenes of this gene are present on chromosomes 4 and 17.
• Alternative splicing results in multiple transcript variants encoding different isoforms.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 0.1-0.5ug/mlWestern Blot: 0.1-0.5ug/mlImmunohistochemistry (paraffin): 0.5-1ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile dH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.